4. THREE MONTHS SUBACUTE TOXICITY OF CAPTOPRIL IN BEAGLE DOGS
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چکیده
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Ultrastructural lesions of pyridoxine toxicity in beagle dogs.
Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxi...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1981
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.6.supplementii_247